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WHEN YOU RECOMMEND DUKORAL® MATTERS – LEARN ABOUT THE DOSING REGIMEN AND ADMINISTRATION

Dosing schedule to prevent diarrhea caused by LT-producing ETEC1

Recommend the vaccine for adults and children over 2 years of age who will be visiting areas posing a risk of diarrheal illness caused by LT-producing ETEC.1

ADULTS AND CHILDREN 2 YEARS AND OLDER TAKING DUKORAL® FOR THE FIRST TIME1

Primary immunization: 2 oral doses

FIRST DOSE at least
2 weeks before departure

SECOND DOSE at least 1 week
after the 1st dose and at least
1 week before departure

PROTECTION starts about
1 week after the 2nd dose and
will last for about 3 months

NOTE: If more than 6 weeks elapse between the 1st and 2nd dose, the primary immunization should be restarted.

BOOSTER1

Suggest a booster dose if your patient has taken DUKORAL® before and is travelling again:
  • If the patient received the last dose between 3 months and 5 years before, one booster dose will be sufficient to renew the protection.
  • If the patient received the last dose more than 5 years before, a complete primary immunization (2 doses) is recommended to renew the protection.

Dosing schedule to prevent cholera1

The vaccine is recommended for adults and children from 2 years of age who will be visiting areas with an ongoing or anticipated epidemic or who will be spending an extended period of time in areas in which cholera infection is a risk.1

ADULTS AND CHILDREN 6 YEARS AND OLDER TAKING DUKORAL® FOR THE FIRST TIME1

Primary immunization: 2 oral doses

FIRST DOSE at least
2 weeks before departure

SECOND DOSE at least 1 week
after the 1st dose and at least
1 week before departure

PROTECTION starts about
1 week after the 2nd dose and
will last for about 2 years

Note: If more than 6 weeks elapse between the 1st and 2nd dose, the primary immunization should be restarted.

CHILDREN AGED BETWEEN 2 AND 6 YEARS OLD TAKING DUKORAL® FOR THE FIRST TIME1

Primary immunization: 3 oral doses

FIRST DOSE at least 3 weeks before departure
SECOND DOSE at least 1 week after the 1st dose
THIRD DOSE at least 1 week after 2nd dose and at least 1 week before departure
PROTECTION against cholera starts about 1 week after the 3rd dose and will last for about 6 months
Note: If more than 6 weeks elapse between any of the doses, the primary immunization should be restarted.

BOOSTER1

Adult and child 6 years and older who has taken DUKORAL® before and is travelling again:

  • If it has been between 2 and 5 years since the patient received the last dose, one booster dose will be sufficient to renew the protection.
  • If it has been more than 5 years since the patient received the last dose, a complete primary immunization (2 doses) is recommended to renew the protection.

Child between 2 and 6 years old who has taken DUKORAL® before and is travelling again:

  • If it has been between 6 months and 5 years since the patient received the last dose, one booster dose will be sufficient to renew the protection.
  • If it has been more than 5 years since the patient received the last dose, a complete primary immunization (3 doses) is recommended to renew the protection.
Booster doses should be recommended to patients who have taken DUKORAL® before and who are travelling to destinations that are at a higher risk for cholera and LT-producing ETEC diarrhea.

Administration

EDUCATE YOUR PATIENTS ON HOW TO CORRECTLY PREPARE DUKORAL® USING THESE 4 STEPS

Locate the two components: effervescent powder (sodium hydrogen carbonate) in a white sachet and the DUKORAL® vaccine vial.1
Prepare the buffer solution (effervescent powder+water mixture) and add the content of the DUKORAL® vaccine vial according to the directions below:
The DUKORAL® vaccine is a whitish suspension in a single-dose glass vial supplied with one sachet (5.6 g) of white effervescent powder with a raspberry flavour.
DUKORAL® is available in package sizes of 1 and 2 doses. One dose DUKORAL® contains approximately 1200 mg sodium.1
The vaccine must be taken orally (by mouth) after mixing the content of the DUKORAL® vaccine vial with the buffer solution.1

STEP 11

To prepare the buffer solution

Open the white sachet containing the effervescent powder (sodium hydrogen carbonate) and pour its content into 150 mL (approx. 5 oz) of cool water. Stir gently with a spoon to dissolve.

Use only cool water to prepare the buffer solution. Do not use any other liquid.

For kids aged 2–6 years, pour away half of the prepared buffer solution before proceeding to Step 2 (keep 75 mL, approx. 2.5 oz).

STEP 21

Shake the DUKORAL® vaccine vial

Shake the DUKORAL® vaccine vial to mix it well (1 vial = 1 dose).

STEP 31

To prepare the vaccine mixture

Open the DUKORAL® vaccine vial from Step 2 and pour its content into the glass of prepared buffer solution from Step 1. Stir gently with a spoon to mix all ingredients.

STEP 41

Drink the vaccine mixture

Drink the entire contents of the glass immediately, as it should be consumed within 2 hours of its preparation. If not consumed immediately, keep at room temperature.

Do not eat or drink anything, including water, for 1 hour after taking DUKORAL®.

IMPORTANT: Patients should not eat or drink any other liquids (including water), or take any other medication for 1 hour before and 1 hour after taking DUKORAL®.
MISSED DOSE: If the 2nd or 3rd dose is missed, it can be taken at any time within six weeks of the previous dose. If more than 6 weeks elapse between any of the doses, the primary immunization should be re-started.1
It is recommended that healthcare professionals record the time and date of administration, quantity of administered dose (if applicable) and route of administration, brand name and generic name of the vaccine, the product lot number and expiry date for safety monitoring and record-keeping purposes.1
DUKORAL® offers patients the convenience of a drinkable vaccine.1

Storage1

Store at 2°C to 8°C (35°F to 46°F).
DO NOT FREEZE
After mixing the content of the DUKORAL® vaccine vial with the buffer solution (effervescent powder+water mixture), the vaccine mixture should be consumed within 2 hours.
Do not use after expiration date.
Keep your patients informed about DUKORAL®

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