INFORM YOUR PATIENTS ABOUT DUKORAL® BEFORE THEIR TRAVELS
DUKORAL® is available as a behind-the-counter medication dispensed by a pharmacist without a prescription (specific to the LT-producing ETEC diarrhea indication) in all Canadian provinces except Quebec and Saskatchewan.*
Keep DUKORAL® in mind, especially during the busy travel season for Canadians.
Offering pre-travel health advice and considering DUKORAL® for your patients can help them prevent and protect against cholera and LT-producing ETEC diarrhea during their travels.
*Clinical significance unknown.
References:
- 1. DUKORAL® Product Monograph. June 26, 2023.
- 2. Canadian Digestive Health Foundation. Dukoral – CDHF Certified Product. August 21, 2023. Available online: https://cdhf.ca/en/dukoral-cdhf-certified-product/. Accessed August 24, 2023.
- 3. Government of Canada. Pathogen Safety Data Sheets: Escherichia coli, enterotoxigenic. Available at: https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/pathogen-safety-data-sheets-risk-assessment/escherichia-coli-enterotoxigenic.html. Accessed November 6, 2025.
- 4. Centers for Disease Control and Prevention. Traveler’s Diarrhea. CDC Yellow Book 2026. May 1, 2023. Available online: https://www.cdc.gov/yellow-book/hcp/preparing-international-travelers/travelers-diarrhea.html. Accessed September 29, 2029.
- 5. Mueller M, et al. Escherichia coli infection. StatPearls. July 13, 2023.
- 6. Isidean SD, et al. A systematic review of ETEC epidemiology focusing on colonization factor and toxin expression. Vaccine 2011; 29:6167–78.
- 7. World Health Organization. Enterotoxigenic Escherichia coli (ETEC). April 30, 2022. Available online: https://www.who.int/teams/immunization-vaccines-and-biologicals/diseases/enterotoxigenic-escherichia-coli-(etec). Accessed August 24, 2023.
- 8. Center for Immunization Research. ETEC (Enterotoxigenic Escherichia Coli). Available online: https://centerforimmunizationresearch.org/research_items/etec/. Accessed August 24, 2023.
- 9. Steffen R. Epidemiology of travellers’ diarrhea. J Travel Med. 2017;24(suppl_1):S2–S5.
- 10. Shah N, et al. Global etiology of traveler’s diarrhea: Systematic Review from 1973 to the present. Am J Trop Med Hyg 2009; 80(4):609–614.
- 11. Mala W, et al. Evidence of pathogens associated with travelers’ diarrhea in Thailand: a systematic review. Trop Dis Travel Med Vaccines. 2025 (11):8.
- 12. Government of Canada. Cholera and ETEC Travellers’ diarrhea vaccine: Canadian Immunization Guide. Available at: https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-3-cholera-enterotoxigenic-escherichia-coli-travellers-diarrhea-vaccine.html#a2. Accessed September 29, 2025.
- 13. World Health Organization. WHO preferred product characteristics for vaccines against enterotoxigenic Escherichia coli. May 31, 2021. Available online: https://iris.who.int/server/api/core/bitstreams/53af87dd-8745-4910-b2f5-538113a8975d/content. Accessed November 4, 2025.
- 14. Henrique C, et al. Heat-Labile Toxin from Enterotoxigenic Escherichia coli Causes Systemic Impairment in Zebrafish Model. Toxins 2021;13:419.
- 15. Khalil I, Walker R, Porter C, et al. Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access. Vaccine 2021;Jul 13;39(31):4266–4277.
- 16. Centers for Disease Control and Prevention. Food and Drinks Considerations When Traveling. Available at: https://wwwnc.cdc.gov/travel/page/food-water-safety. Accessed November 6, 2025.
- 17. Kozicki M., et al. Boil it, cook it, peel it or forget it: does this rule prevent travellers’ diarrhoea?. International journal of epidemiology. 1985:14(1), 169–172.
- 18. Hsiao A, et al. Lessons learnt from 12 oral cholera vaccine campaigns in resource-poor settings. Bulletin of the World Health Organization 2017;95:303–312.
- 19. World Health Organization. Cholera Fact sheet. December 5, 2024. Available online: https://www.who.int/news-room/fact-sheets/detail/cholera. Accessed November 6, 2025.
- 20. World Health Organization. Cholera: WHO Health Emergency Appeal 2025. January 16, 2025. Available online: https://www.who.int/publications/m/item/cholera–who-health-emergency-appeal-2025. Accessed November 6, 2025.
- 21. European Centre for Disease Prevention and Control. Cholera worldwide overview. Available at: https://www.ecdc.europa.eu/en/all-topics-z/cholera/surveillance-and-disease-data/cholera-monthly. Accessed November 6, 2025.
- 22. Center for Disease Control and Prevention. Cholera. May 29, 2025. Available online: https://www.cdc.gov/cholera/about/index.html. Accessed November 6, 2025.
- 23. DUKORAL® Data on File. 2025.
