INFORM YOUR PATIENTS ABOUT DUKORAL® BEFORE THEIR TRAVELS
DUKORAL® is available as a behind-the-counter medication dispensed by a pharmacist without a prescription (specific to the LT-producing ETEC diarrhea indication) in all Canadian provinces except Quebec and Saskatchewan.*
Keep DUKORAL® in mind, especially during the busy travel season for Canadians.
Offering pre-travel health advice and considering DUKORAL® for your patients can help them prevent and protect against cholera and LT-producing ETEC diarrhea during their travels.
*Clinical significance unknown.
References:
- 1. DUKORAL® Product Monograph. June 26, 2023.
- 2. Canadian Digestive Health Foundation. Dukoral – CDHF Certified Product. August 21, 2023. Available online: https://cdhf.ca/en/dukoral-cdhf-certified-product/. Accessed August 24, 2023.
- 3. Center for Disease Control and Prevention. Enterotoxigenic E. coli (ETEC). December 1, 2014. Available online: https://www.cdc.gov/ecoli/etec.html. Accessed August 24, 2023.
- 4. Centers for Disease Control and Prevention. Traveler’s Diarrhea. CDC Yellow Book 2024. May 1, 2023. Available online: https://wwwnc.cdc.gov/travel/yellowbook/2024/preparing/travelers-diarrhea. Accessed August 24, 2023.
- 5. Mueller M, et al. Escherichia coli infection. StatPearls. July 13, 2023
- 6. Isidean SD, et al. A systematic review of ETEC epidemiology focusing on colonization factor and toxin expression. Vaccine 2011; 29:6167–78.
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- 8. Center for Immunization Research. ETEC (Enterotoxigenic Escherichia Coli). Available online: https://centerforimmunizationresearch.org/research_items/etec/. Accessed August 24, 2023.
- 9. Steffen R. Epidemiology of travellers’ diarrhea. J Travel Med. 2017;24(suppl_1):S2–S5.
- 10. Shah N, et al. Global etiology of traveler’s diarrhea: Systematic Review from 1973 to the present. Am J Trop Med Hyg 2009; 80(4):609–614.
- 11. World Health Organization. WHO preferred product characteristics for vaccines against enterotoxigenic Escherichia coli. May 31, 2021. Available online: https://www.who.int/publications/i/item/who-preferred-product-characteristics-for-vaccines-against-enterotoxigenic-escherichia-coli. Accessed August 24, 2023.
- 12. Henrique C, et al. Heat-Labile Toxin from Enterotoxigenic Escherichia coli Causes Systemic Impairment in Zebrafish Model. Toxins 2021;13:419.
- 13. Khalil I, Walker R, Porter C, et al. Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access. Vaccine 2021;Jul 13;39(31):4266–4277.
- 14. Center for Disease Control and Prevention. Food and Drink Considerations When Traveling. July 13, 2023. Available online: https://wwwnc.cdc.gov/travel/page/food-water-safety. Accessed August 24, 2023.
- 15. Kozicki, M., Steffen, R., & Schär, M. (1985). 'Boil it, cook it, peel it or forget it': does this rule prevent travellers' diarrhoea?. International journal of epidemiology, 14(1), 169–172. https://doi.org/10.1093/ije/14.1.169
- 16. Mohammad A, et al. The global burden of cholera. Bulletin of the World Health Organization 2012; 90(3):209–218A.
- 17. World Health Organization. Cholera Fact sheet. March 30, 2022. Available online: https://www.who.int/news-room/fact-sheets/detail/cholera. Accessed August 24, 2023.
- 18. Hsiao A, et al. Lessons learnt from 12 oral cholera vaccine campaigns in resource-poor settings. Bulletin of the World Health Organization 2017;95:303–312.
- 19. Center for Disease Control and Prevention. Cholera – General Information. August 7, 2023. Available online: https://www.cdc.gov/cholera/general/index.html#:~:text=Cholera%20is%20most%20likely%20to,been%20a%20source%20of%20infection. Accessed August 24, 2023.
- 20. World Health Organization. Cholera 2022 Weekly epidemiological report. Available online: https://iris.who.int/bitstream/handle/10665/372986/WER9838-eng-fre.pdf?sequence=1&isAllowed=y. Accessed October 24, 2023.
- 21. World Health Organization. Multi-country outbreak of cholera. Available online: https://www.who.int/publications/m/item/multi-country-outbreak-of-cholera–external-situation-report–7—5-october-2023. Accessed October 24, 2023.
- 22. Center for Disease Control and Prevention. Cholera. August 10, 2023. Available online: https://wwwnc.cdc.gov/travel/diseases/cholera. Accessed August 24, 2023.
- 23. Government of Canada. Cholera and enterotoxigenic Escherichia coli (ETEC) travellers’ diarrhea vaccine: Canadian Immunization Guide. September 8, 2023. Available at: https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-3-cholera-enterotoxigenic-escherichia-coli-travellers-diarrhea-vaccine.html#t1. Accessed September 19, 2023.
- 24. DUKORAL® Data on File. 2023.
